Seminar Series - Meghan Ruebel

Postdoctoral Candidate
Arkansas Children’s Nutrition Center

Friday, April 15th, 2016
11:00 AM-12:00 PM

1310 Anthony Hall Building
East Lansing, MI
Videoconference to Grand Rapids 438 Secchia

Title: Maternal obesity programming from the ovary to the oocyte transcriptome

Exposure to maternal obesity during development leads to increased risk of obesity in adult-life. However, whether programming is initiated in utero or during the peri-conception period is yet unknown. This work focused on characterizing the effects of maternal obesity programing on the whole ovary and oocyte. We hypothesized that obesity will induce an ovarian inflammatory gene expression programming, involving, among others, the upregulation of Egr-1 signaling, that could be detected at the level of ovarian gene expression, and follicular fluid inflammatory cytokine content. We also hypothesized that these inflammatory changes influenced gene expression in the ovulating oocyte itself, potentially programming any resulting offspring to an obesogenic phenotype. We used a translational approach to test our hypotheses. This presentation will show data on the effects of maternal obesity programming from the ovary to the oocyte transcriptome in both rat and human samples.

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