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Bin Gu


Ph.D. Zhejiang University, Hangzhou, China

B.A. Zhejiang University, Hangzhou, China

Postdoctoral Research, The Hospital for Sick Children, Toronto, Canada

Research Interests

The focus of our research is investigating the molecular mechanisms regulating early embryo development, infertility and genetic disease. We develop new genome engineering technology to generate mouse models for complex mutations discovered in human fertility defects and genetic diseases. We study them using cutting-edge technologies, such as live imaging and in-vivo genetic engineering, to understand the mechanism and develop new treatments.

Research Topics

  • Developmental Biology
  • Embryogenesis
  • Genome editing
  • Disease modeling

Representative Publications

Gu B., Posfai E. and Rossant J. Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos. Nat Biotechnol 36, 632-637, doi:10.1038/nbt.4166 (2018).

Erwood, S.; Gu, B., Embryo-Based Large Fragment Knock-in in Mammals: Why, How and What's Next. Genes (Basel) 2020, 11 (2).

Gu, B., Lambert, J. P., Cockburn, K., Gingras, A. C. & Rossant, J. AIRE is a critical spindle-associated protein in embryonic stem cells. Elife 6, doi:10.7554/eLife.28131 (2017).

NCBI Publications