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Biography

hoffman

Education

  • D. 12/2010 - Neurobiology, Montpellier University 2, France, European mention
  • D. 12/2010 - Biochemistry, Autonomous University of Barcelona, Spain, Cum Laude
  • Postdoc 06/11-03/17 - Department of Reproductive Medicine, UC San Diego.

Research

Dr. Hoffmann’s research program is focused on understanding the molecular pathways and brain circuitry regulating function of the hypothalamus and the suprachiasmatic nucleus (SCN), the major pacemaker of the body, and how their impaired function affects hormone release, behavior and reproductive competence. Uncoordinated hormone release, as seen in

shift workers and people sitting in front of bright screens late into the night, is a growing health concern and affects more than 20% of the US population. Not only do impaired circadian rhythms increase the risk of endocrine disorders such as diabetes, obesity, and cardiovascular disease, but they also affect mental health and lead to infertility and might be associated with poor labor outcomes. To further our understanding of the importance of circadian rhythms in endocrine-related disorders and fertility, Dr. Hoffmann has developed novel mouse models allowing her to understand the central and peripheral control of reproductive function.

The major goal of Dr. Hoffmann’s research is to understand how abnormal SCN function leads to desynchronization of hormone release and how this relates to cellular function and fertility. Her long-term goal is to identify novel drug targets for the treatment of arrhythmia, infertility and mis-timed labor.

Dr. Hoffmann’s current projects use numerous molecular biology approaches, including novel transgenic mouse models, reporter mice (Per2::luciferase, TdTomato, etc), and recordings from live cells and tissues, in combination with behavioral studies.

Research topics

  • Reproduction
  • Pregnancy
  • Preterm Labor
  • Neuro-endocrinology
  • Molecular Biology
  • Circadian rhythms
  • Development
  • Receptor-induced signaling

Awards

2014 - Early Career Forum Travel award for ICE/ENDO 2014 in Chicago, IL (Women in Endocrinology)

2015 - Endocrine Society Outstanding Abstract Award (ENDO 2015)

2016 - Neena Schwartz Young Investigator Award in Basic Science (Women in Endocrinology)

2016 - Early Investigators Award supported by Merck & Co., Inc. (Endocrine Society)

2017 - New Investigator Award (Society for Behavioral Neuroendocrinology)

2019 – Basil O’Connor Starter Scholar Research Awards (March of Dimes)

NCBI-My Bibliography

Lab Website