The past two decades have ushered in landmark discoveries in the reproductive and developmental sciences of significant potential impact to human health and animal agriculture, including advancements in assisted reproductive technologies and derivation of human embryonic and induced pluripotent stem cells and the transition of regenerative medicine from the realm of theory to application. Michigan State University has a long history of excellence in the reproductive and developmental sciences, and is unique in having both cutting-edge research in the reproductive and developmental sciences across a wide range of animal models, clinical entities and in population-based human reproductive outcomes all on a single campus. The Reproductive and Developmental Sciences Program (RDSP) is composed of a strong and interactive group of faculty from the College of Human Medicine, College of Veterinary Medicine and the College of Agriculture and Natural Resources with diverse expertise and research interests who are engaged in fundamental and translational research geared towards advancements in regenerative medicine.
Vision: To be the leading Center of Excellence in the Reproductive and Developmental Sciences and enhance research partnerships with other research universities and international entities and uphold the traditions of an exceptional land grant institution.
Mission: The overall goal of the Reproductive and Developmental Sciences Program at Michigan State University is to leverage and expand ongoing collaborations between faculty working in animal science, human medicine, veterinary medicine, genetics, and regenerative medicine and to further formalize this unique trans disciplinary focus in a manner that will enhance the rate of scientific discovery and the quality of graduate and postdoctoral training.
|March 5, 2018||Anthony Hall 1310/GRRC 1102||Guest Lecturer||Dr. Sun-Wei Guo “The quest for the Holy Grail of the natural history of endometriosis”.|
|March 19, 2018||Anthony Hall 1310/GRRC 1102||RIP Meeting (Trainee)||Dr. Brad Daigneault (Smith Lab)|
|March 26, 2018||Anthony Hall 1310/GRRC 1102||Guest Lecturer||Dr. Bruce Lessey “Inflammation and Endometriosis: Pathway to Infertility and Cancer”|
Pachytene piRNAs are the most abundant piRNAs in mammalian adult testes. They aregenerated from long precursor transcripts by the primary piRNA biogenesis pathway but thefactors involved in pachytene piRNA precursors processing are poorly understood. Here weshow that the Tudor domain-containing 5 (TDRD5) protein is essential for pachytene piRNAbiogenesis in mice. Conditional inactivation of TDRD5 in mouse postnatal germ cells revealsthat TDRD5 selectively regulates the production of pachytene piRNAs from abundant piRNA-producing precursors, with little effect on low-abundant piRNAs. Unexpectedly, TDRD5 is notrequired for the 5′end processing of the precursors, but is crucial for promoting production ofpiRNAs from the other regions of the transcript. Furthermore, we show that TDRD5 is anRNA-binding protein directly associating with piRNA precursors. These observationsestablish TDRD5 as a piRNA biogenesis factor and reveal two genetically separable steps atthe start of pachytene piRNA processing
MARINE BIOLOGY LABORATORY | Woods Hole, MA
COURSE DIRECTOR: Rafael Fissore, University of Massachusetts, Amherst
Rafael Fissore, University of Massachusetts, Amherst This is an intensive, mentored training program in animal and human reproductive biology designed to transmit the latest conceptual advances in the field and provide hands-on experience with techniques used in research labs and in clinics. The ultimate goal is to train the future leaders in the field to improve reproductive outcomes in humans and animals. Topics covered include the hypothalamic-pituitary-gonadal axis; stem cells, gametogenesis and fertilization; assisted reproductive technologies; placentation and implantation strategies across species.
April 28 – June 10, 2018 | Application deadline January 18, 2018
* The MBL is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and an affiliate of the University of Chicago.
Asgi Fazleabas, Professor and Associate Chair for Research, Department of Obstetrics, Gynecology & Reproductive Biology, College of Human Medicine, named University Distinguished Professor in 2017. This recognition is among the highest honors that can be bestowed on a faculty member at Michigan State University.
Scientists at Michigan State University might have uncovered the key to developing an effective male birth control pill.
In studying the causes of male fertility and infertility and using a new gene editing technology, researchers discovered that they can effectively block the gene that controls sperm production in mice, rendering them infertile.
New research offers a genetic foundation for male birth control beyond condoms or vasectomies.
As reported in Nature Communications, Chen Chen, assistant professor of animal science at Michigan State University, and a team of scientists turned off the gene that controls sperm production, effectively silencing spermatogenesis in mice.